Program of Study: Dentistry
Schedule: 15 hours of lectures, 15 hours of exercises
Course Distribution: 4th year, 7th term
Number of Credits: 2
Course Form: Lectures and exercises
Requirements: Attendance of all teaching session is required to obtain the "Practicavit" signature.
Completed by: Practicavit, examination
Rabson A, Roitt IM, Delves PJ: Really Essential Immunology
A) THEORETICAL IMMUNOLOGY
- What is immunology, immunity, relation to neuroendocrine system.
- Structure of the lymphatic system - primary and secondary lymphatic organs.
- Cell elements involved in non-specific immune response - epithelial cells, leukocytes, and non-haematopoietic cells.
- Antigen presenting cells - involvement in the induction of immune response, classification.
- Cell elements involved in antigen specific immune defense.
- Relationship between cell of the innate and antigen specific immunity.
- Humoral factors of defense in systemic, mucosal and skin immunity (specific and non specific).
- Classical, lectin, and alternative cascade of complement - biological sense, differences.
- Antibodies - isotypes and subclasses, physiological concentrations, function in systemic and mucosal immunity.
- IgA as the major factor of mucosal immunity.
- The course of B cells activation, primary and secondary antibody response.
- IgE - involvement in immune responses, interaction with cell surface receptors.
- Genetic base of antibody variability, genetic recombination, sources of variability of VH a VL.
- Antigens, haptens, carriers, allergen, autoantigen, superantigens.
- T dependent and independent antigens.
- 21. MHC, genomic localization, cellular distribution, hereditability, biological sense of MHC variability.
- Cytokines and chemokines - classification, biological sense.
- T-cells, CD classification, biological sense, functions, physiological concentration in circulation.
- Th cells - classification, functions, cooperation with other cell elements.
- Regulatory CD4, CD8 T cells, the mechanisms of regulatory activity.
- Cytotoxic T cell , effector and memory functions.
- NK cells - effector functions cytotoxic and regulatory.
- 31. Antigen-specific and non-specific cooperation of T a B cells during development of antibody response.
- Mucosal immunity as a homeostatic barrier on the border of external and systemic immunity
- The mucosal immune system of the oral cavity.
B) LABORATORY AND CLINICAL IMMUNOLOGY
- Investigation of the patient with suspected allergic/immunological disorder - anamnesis, physical and laboratory examinations.
- Sampling of the patients for immunological laboratory investigation - indication, specimens collection, storage, results interpretation.
- Laboratory tests for evaluation of humoral immunity - methods, reference values, indication, interpretation.
- Laboratory tests for evaluation of lymphocyte populations counts and functions - methods, reference values, indication, interpretation.
- Laboratory tests for evaluation of phagocytes - methods, reference values, indication, interpretation.
- HLA-typing - methods, indication, interpretation.
- Genotyping tests for clinical immunology - PCR, Sanger sequencing, NGS-based tests - principles, differences.
- 9. Principles of the investigation of the allergic patient - anamnesis, physical investigation, skin tests, exposition, elimination, and bronchoprovocation tests - indication, interpretation.
- Immunological mechanisms involved in etiopathology periodontitis.
- Immediate (type I) hypersensitivity reactions - principles, clinical manifestation. Atopy.
- Pathophysiological role of IgE in allergy and asthma.
- Cytotoxic (type II) hypersensitivity reactions - principles, clinical manifestation.
- Immune complexes (type III) hypersensitivity reactions - principles, clinical manifestation.
- Delayed hypersensitivity (type IV) reactions - principles, clinical manifestation.
- Cell elements involved in allergic reaction, mediators of allergic reaction.
- Seasonal allergic rhinitis (hay fever, polinosis) and persistent (perennial) allergic and non-allergic rhinitis - etiopathology, clinical manifestations, therapy.
- Allergic asthma - classification, clinical manifestation, therapy.
- Drug allergy - symptoms, diagnosis, treatment.
- Skin allergy (eczema, hives, allergic contact dermatitis), allergic march, Quincke's edema, HAE - etiopathology, symptoms, diagnosis, thetapy.
- Hymenoptera venom allergy, symptoms, diagnosis, therapy.
- Oral Manifestations of immunodeficiencies and autoimmne disorders.
- Primary and secondary immunodeficiencies - classification, etiopathology, clinical manifestation.
- Immune stimulation, immunosuppressive, and immune modulation therapy. Biologic therapy.
- Allergen-specific immunotherapy - principles, indications, practice of administering, types.